Journal article
Evidence for a role of GABA and Mas-allatotropin in photic entrainment of the circadian clock of the cockroach Leucophaea maderae.



Publication Details
Authors:
Stengl, M.
Publication year:
2002
Journal:
Journal of Experimental Biology
Pages range:
1459-69
Volume number:
205
ISSN:
0022-0949

Abstract
Accumulating evidence suggests that the accessory medulla is the location of the circadian pacemaker in the fruit fly Drosophila melanogaster and the cockroach Leucophaea maderae. gamma-Aminobutyric acid (GABA) and Mas-allatotropin are two putative neurotransmitters, in the accessory medulla in the cockroach Leucophaea maderae. Neurons immunoreactive to the neuropeptide Mas-allatotropin are local neurons with arborizations in the noduli of the accessory medulla, while GABA-immunoreactive neurons connect the noduli of the accessory medulla to the medulla and to the lamina via processes in the distal tract. Injections of GABA and Mas-allatotropin into the vicinity of the accessory medulla resulted in stable phase-dependent resetting of the circadian locomotor activity of the cockroach. The resulting phase response curves closely matched light-dependent phase response curves, suggesting that both substances play a role in circuits relaying photic information from circadian photoreceptors to the central pacemaker.


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