Journal article
Silanetriols as in vitro inhibitors for AChE.



Publication Details
Authors:
Blunder, M.; Hurkes, N.; Spirk, S.; List, M.; Pietschnig, R.
Publisher:
Elsevier B.V.DO - 10.1016/j.bmcl.2010.10.139
Publication year:
2011
Journal:
Bioorganic and Medicinal Chemistry Letters
Pages range:
363-365
Volume number:
21
Start page:
363
End page:
365
ISSN:
0960-894X

Abstract
Three stable silanetriols with increasing steric protection of the silicon atom have been tested for inhibition of acetylcholinesterase (AChE). For all tested silanetriols we found reversible inhibition of the AChE activity at a 100 μM concn. The highest inhibition rate was found for the sterically least hindered cyclohexylsilanetriol with 45% inhibition relative to galanthamine hydrobromide for which an IC50 value of 121±3 μM was detd. as well. The cytotoxicity of the silanetriols used was negligible at concns. relevant for inhibition. [on SciFinder(R)]


Keywords
silanetriol steric protection acetylcholinesterase inhibitor


Authors/Editors

Last updated on 2019-25-07 at 16:02