Aufsatz in einer Fachzeitschrift
An Age-Dependent Interaction with Leptin Unmasks Ghrelin's Bone-Protective Effects



Details zur Publikation
Autor(inn)en:
van der Velde, M.; van der Eerden, B.; Sun, Y.; Almering, J.; van der Lely, A.; Delhanty, P.; Smith, R.; van Leeuwen, J.
Publikationsjahr:
2012
Zeitschrift:
Endocrinology
Seitenbereich:
3593-3602
Jahrgang/Band:
153
Erste Seite:
3593
Letzte Seite:
3602
ISSN:
0013-7227

Zusammenfassung, Abstract
The mutual interplay between energy homeostasis and bone metabolism is an important emerging concept. Ghrelin and leptin antagonize each other in regulating energy balance, but the role of this interaction in bone metabolism is unknown. Using ghrelin receptor and leptin-deficient mice, we show that ghrelin has dual effects on osteoclastogenesis, inhibiting osteoclast progenitors directly and stimulating osteoclastogenesis via a more potent systemic/central pathway. Using mice with combined ghrelin receptor and leptin deficiency, we find that this systemic osteoclastogenic activity is suppressed by leptin, thus balancing the two counterregulatory ghrelin pathways and leading to an unchanged bone structure. With aging, this osteoclastogenic ghrelin pathway is lost, unmasking the direct protective effect of ghrelin on bone structure. In conclusion, we identify a novel regulatory network linking orexigenic and anorectic metabolic factors with bone metabolism that is age dependent.


Autor(inn)en / Herausgeber(innen)

Zuletzt aktualisiert 2019-25-07 um 11:50