Aufsatz in einer Fachzeitschrift
Catalytic enantioslective addition of diethylzinc to 1,3-dithian-2-yl substituted aliphatic aldehydes: a new approach to optically active 2-(hydroxyalkyl)-1,3-dithianes



Details zur Publikation
Autor(inn)en:
Wilken, J.; Winter, M.; Stahl, I.; Martens, J.
Publikationsjahr:
2000
Zeitschrift:
Tetrahedron: Asymmetry
Seitenbereich:
1067-1071
Jahrgang/Band:
11
ISSN:
0957-4166

Zusammenfassung, Abstract
Asymmetric synthesis of 2-(hydroxyalkyl)-1,3-dithianes was achieved in good yields of up to 81% by using various 1,3-dithian-2-yl-substituted aliphatic aldehydes as substrates in the catalytic enantioselective addition of diethylzinc, With fair enantiomeric ratios of up to 85:15 in the enantiocontrolled ethylation step this synthetic approach provides an entry towards potential chiral building blocks. (C) 2000 Elsevier Science Ltd. All rights reserved.

Zuletzt aktualisiert 2019-01-11 um 16:05