Aufsatz in einer Fachzeitschrift
Two substrates are better than one: dual specificities for Dnmt2 methyltransferases



Details zur Publikation
Autor(inn)en:
Nellen, W.
Publikationsjahr:
2006
Zeitschrift:
Trends in Biochemical Sciences
Seitenbereich:
306-308
Jahrgang/Band:
31
Erste Seite:
306
Letzte Seite:
308
ISSN:
0968-0004

Zusammenfassung, Abstract
Dnmt2 enzymes have been widely conserved during evolution and contain all of the signature motifs of DNA (cytosine-5)-methyltransferases; however, the DNA methyltransferase activity of these proteins is comparatively weak and their biochemical and functional properties remain enigmatic. Recent evidence now shows that Dnmt2 has a novel tRNA methyltransferase activity, raising the possibility that the biological roles of these proteins might be broader than previously thought. This finding has important implications for understanding the evolutionary relationships among these enzymes.


Autor(inn)en / Herausgeber(innen)

Zuletzt aktualisiert 2019-01-11 um 16:04