Journal article
Inositol-trisphosphate-dependent calcium currents precede cation currents in insect olfactory receptor neurons.



Publication Details
Authors:
Stengl, M.
Publication year:
1994
Journal:
Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Pages range:
187-194
Volume number:
174
ISSN:
0340-7594

Abstract
Specialized olfactory receptor neurons in insects respond to species-specific sex pheromones with transient rises in inositol trisphosphate and by opening pheromone-dependent cation channels. These channels resemble cation channels which are directly or indirectly Ca2+-dependent. But there appear to be no internal Ca2+ stores in the outer dendrite where the olfactory transduction cascade is thought to start. Hence, it remains to be determined whether an influx of external Ca2+ precedes pheromone-dependent cation currents. Patch clamp measurements in cultured olfactory receptor neurons from Manduca sexta reveal that a transient inward current precedes pheromone-dependent cation currents. A transient inositol trisphosphate-dependent Ca2+ current, also preceding cation currents with the characteristics of pheromone-dependent cation currents, shares properties with the transient pheromone-dependent current. These results match the biochemical measurements with the electrophysiological data obtained in insect olfactory receptor neurons.


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Last updated on 2019-25-07 at 13:52