Journal article
Biomolecular structure manipulation using tailored electromagnetic radiation: a proof of concept on a simplified model of the active site of bacterial DNA topoisomerase.



Publication Details
Authors:
Jarukanont, D.; Garcia, M.; Patel, S.; Ramos, M.; Coimbra, J.; Bauerhenne, B.; Fernandes, P.
Publication year:
2014
Journal:
Physical Chemistry Chemical Physics
Pages range:
21768-77
Volume number:
16
Issue number:
39
Start page:
21768
End page:
77
ISSN:
1463-9076
eISSN:
1463-9084

Abstract
We report on the viability of breaking selected bonds in biological systems using tailored electromagnetic radiation. We first demonstrate, by performing large-scale simulations, that pulsed electric fields cannot produce selective bond breaking. Then, we present a theoretical framework for describing selective energy concentration on particular bonds of biomolecules upon application of tailored electromagnetic radiation. The theory is based on the mapping of biomolecules to a set of coupled harmonic oscillators and on optimal control schemes to describe optimization of temporal shape, the phase and polarization of the external radiation. We have applied this theory to demonstrate the possibility of selective bond breaking in the active site of bacterial DNA topoisomerase. For this purpose, we have focused on a model that was built based on a case study. Results are given as a proof of concept.


Authors/Editors

Last updated on 2019-01-03 at 10:49