Aufsatz in einer Fachzeitschrift
Control of cleavage cycles in Drosophila embryos by fruhstart



Details zur Publikation
Autor(inn)en:
Müller, H.; Grosshans, J.; Kessler, T.
Verlag:
CELL PRESS
Publikationsjahr:
2003
Zeitschrift:
Developmental Cell
Seitenbereich:
285-294
Jahrgang/Band:
5
Heftnummer:
2
Erste Seite:
285
Letzte Seite:
294
Seitenumfang:
10
ISSN:
1534-5807

Zusammenfassung, Abstract
Early metazoan development consists of cleavage stages characterized by rapid cell cycles that successively divide the fertilized egg. The cell cycle oscillator pauses when the ratio of DNA and cytoplasm (N/C) reaches a threshold characteristic for the species. This pause requires maternal factors as well as zygotic expression of as yet unknown genes. Here we isolate the zygotic gene fruhstart of Drosophila and show that it is involved in pausing the cleavage cell cycle. frs is expressed immediately after the last cleavage division. It plays a role in generating a uniform pause and it can inhibit cleavage divisions when precociously expressed. Furthermore, the expression of frs is delayed in haploid embryos and requires activity of the maternal checkpoint gene grapes. We propose that zygotic frs expression is involved in linking the N/C and the pause of cleavage


Autor(inn)en / Herausgeber(innen)

Zuletzt aktualisiert 2019-25-07 um 19:25