Review
Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster



Publication Details
Authors:
Muha, V.; Müller, H.
Publisher:
MDPI AG
Publication year:
2013
Journal:
International Journal of Molecular Sciences
Pages range:
5920-5937
Volume number:
14
Issue number:
3
Start page:
5920
End page:
5937
Number of pages:
18
ISSN:
1661-6596

Abstract
Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell-cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.


Keywords
Cell migration, Cell signalling, Development, differentiation, Drosophila, Fibroblast growth factor


Authors/Editors

Last updated on 2019-25-07 at 19:25

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