Journal article
Wobble uridine modifications-a reason to live, a reason to die?!



Publication Details
Authors:
Schaffrath, R.; Leidel, S.
Publisher:
TAYLOR & FRANCIS INC
Publication year:
2017
Journal:
RNA Biology
Pages range:
1209-1222
Volume number:
14
Issue number:
9
Start page:
1209
End page:
1222
Number of pages:
14
ISSN:
1547-6286

Abstract
Wobble uridines (U-34) are generally modified in all species. U-34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecular machinery required to introduce these modifications into tRNA posttranscriptionally and discuss how posttranslational regulation may affect the activity of the modifying enzymes. We highlight the activity of anticodon specific RNases that target U-34 containing tRNA. Finally, we discuss how defects in wobble uridine modifications lead to phenotypes in different species. Importantly, this review will mainly focus on the cytoplasmic tRNAs of eukaryotes. A recent review has extensively covered their bacterial and mitochondrial counterparts.(1)


Keywords
Anticodon wobble base, protein homeostasis, RNases, stress responses, tRNA modification

Last updated on 2019-25-07 at 18:57