Journal article
Polysomnographic findings in restless legs syndrome (RLS) patients with sever augmentation



Publication Details
Authors:
Steinke, S.; Trenkwalder, C.; Zimmermann, J.; Sixel-Doering, F.; Muntean, M.
Publisher:
ELSEVIER SCIENCE BV
Publication year:
2018
Journal:
Sleep Medicine
Pages range:
79-85
Volume number:
48
Start page:
79
End page:
85
Number of pages:
7
ISSN:
1389-9457

Abstract
Background and objectives: Augmentation can occur frequently in restless legs syndrome (RLS) patients treated with dopaminergic agents. Video-polysomnographic (PSG) data from augmented RLS patients are scant. The aim of this study was to evaluate PSG findings in augmented RLS patients and compare them with those of non-augmented RLS patients.Patients and methods: Valid PSG data were analyzed from 99 augmented and 84 non-augmented RLS inpatients who underwent one night PSG.Results: Both patient groups showed a high subjective burden of RLS symptoms. The mean scores on the International RLS Study Group Rating Scale (IRLS) were significantly higher in the group with augmentation than in the group without. The periodic leg movement index (PLMI) was increased in both groups, mostly on account of the PLM in wakefulness (PLMW). Both groups presented a reduced sleep efficiency and an increased sleep latency. The levodopa equivalent dose (LED) was significantly higher in the augmented group.Conclusions: Our study confirms that RLS patients with augmentation have disturbed sleep due to high amount of leg movements and fragmented sleep. Overall, however, polysomnographic characteristics were not different between insufficiently treated RLS and severely augmented RLS patients, implying that augmentation could represent a severe form of RLS and not a different phenomenon. (C) 2018 Elsevier B.V. All rights reserved.


Keywords
Augmentation, Polysomnography, Restless legs syndrome

Last updated on 2019-30-08 at 21:48