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Clinically relevant cut-off values for the Parkinson's Disease Sleep Scale-2 (PDSS-2): a validation study

Details zur Publikation
Muntean, M.; Benes, H.; Sixel-Döring, F.; Chaudhuri, K.; Suzuki, K.; Hirata, K.; Zimmermann, J.; Trenkwalder, C.
Sleep Medicine

Zusammenfassung, Abstract
BACKGROUND Sleep disturbances are a major problem encountered by neurologists attending Parkinson's disease (PD) patients. The Parkinson's Disease Sleep Scale-2 (PDSS-2) assesses a wide spectrum of disease-specific sleep problems and is easy to administer as a patient self-rating scale. The validation study showed that the scale is reliable, valid, and precise. Until now, however, only one Japanese study has assessed cut-off scores to define poor sleepers. OBJECTIVES In this context we aimed to determine the PDSS-2 cut-off values that define a sleep disturbance severe enough to require referral of the patient to a sleep center or the need for specific treatment. METHODS Inpatients with idiopathic PD consecutively admitted to our hospital were enrolled. Patients completed the PDSS-2. The attending physician, who was blinded to the PDSS-2 results, but familiar with the patients' history and current disease status, completed a questionnaire consisting of two general questions on the presence of PD-specific and non-PD related sleep problems. Statistical analysis was performed to determine cut-off values for the PDSS-2 and correlation with the physician's evaluation of sleep disturbance severity. A natural cohort of non-PD patients with sleep disorders represented the control group. RESULTS The sample consisted of 52 (56{\%}) men and 41 (44{\%}) women with an average age of 69.22 $\pm$ 8.74 years. PDSS-2 showed a sensitivity of 77.6{\%} and a specificity of 74.3{\%} in relation to physician's evaluation of PD-specific sleep problems. According to the physician's evaluation, PD-specific sleep disturbances occurred in 62{\%} of the patients. 83{\%} of patients with PDSS-2 scores $\geq$18 had clinically relevant sleep disturbances compared to only 33{\%} of PD patients with scores {\textless}18. The severity of PD-specific sleep problems was well correlated with the PDSS-2 total score (r = 0.49). CONCLUSIONS To our knowledge, this is the first study to define PDSS-2 cut-off values for the severity of sleep disturbances in a European PD sample. Our study shows that scores $\geq$18 define clinically relevant PD-specific sleep disturbances.

Zuletzt aktualisiert 2019-30-08 um 21:47