Journal article
Overcoming treatment resistance in chronic depression: a pilot study on outcome and feasibility of the cognitive behavioral analysis system of psychotherapy as an inpatient treatment program

Publication Details
Brakemeier, E.; Radtke, M.; Radtke, M.; Engel, V.; Zimmermann, J.; Tuschen-Caffier, B.; Hautzinger, M.; Schramm, E.; Berger, M.; Normann, C.
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Psychotherapy and Psychosomatics
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BACKGROUND The Cognitive Behavioral Analysis System of Psychotherapy (CBASP), initially developed as an outpatient treatment for chronic depression (CD), has been adapted as a multidisciplinary 12-week inpatient program for CD. METHODS Seventy inpatients with CD and treatment resistance were included in a noncontrolled trial. The Hamilton Depression Rating Scale served as the primary outcome measure. Prospective naturalistic follow-up assessments were conducted 6 and 12 months after discharge. RESULTS Dropout rate was 7.1{\%}; 90.4{\%} perceived the program as helpful. Pre-post comparisons yielded strong effect sizes; 75.7{\%} of the intention-to-treat sample responded, and 40.0{\%} remitted. Nonremission was associated with experiencing temporary deterioration of symptoms during treatment. After 6 months 75.0{\%} and after 12 months 48.0{\%} of patients sustained response. CONCLUSIONS The CBASP program appears as a feasible acute treatment for treatment-resistant CD inpatients with promising outcome. However, the continuation of treatment after discharge should be optimized especially for patients with subjective deterioration during treatment.

Last updated on 2019-30-08 at 21:47