Review
Induction of protein aggregation and starvation response by tRNA modification defects



Publication Details
Authors:
Schaffrath, R.
Publisher:
SPRINGER
Publication year:
2020
Journal:
Current Genetics
Pages range:
1053-1057
Volume number:
66
Issue number:
6
Start page:
1053
End page:
1057
Number of pages:
5
ISSN:
0172-8083

Abstract
Posttranscriptional modifications of anticodon loops contribute to the decoding efficiency of tRNAs by supporting codon recognition and loop stability. Consistently, strong synthetic growth defects are observed in yeast strains simultaneously lacking distinct anticodon loop modifications. These phenotypes are accompanied by translational inefficiency of certain mRNAs and disturbed protein homeostasis resulting in accumulation of protein aggregates. Different combinations of anticodon loop modification defects were shown to affect distinct tRNAs but provoke common transcriptional changes that are reminiscent of the cellular response to nutrient starvation. Multiple mechanisms may be involved in mediating inadequate starvation response upon loss of critical tRNA modifications. Recent evidence suggests protein aggregate induction to represent one such trigger.


Keywords
Protein aggregation, Starvation response, tRNA modification

Last updated on 2021-26-04 at 15:55