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Biophysics

University of Kassel » Fachbereiche » Faculty of Mathematics and Natural Sciences » Institut für Biologie

URL:	http://www.uni-kassel.de/fb10/de/institute/biologie/fachgebiete/biophysik-dach.html

Address:

Heinrich-Plett-Str. 40
34130 Kassel

Persons

Prof. Dr. Jörg Η. Kleinschmidt

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Projects

12/2008 - 09/2021	Insertion and folding of beta-barrel membrane proteins into lipid bilayers - Functions of BamA (YaeT) and of membrane anchored Bam lipoproteins in membrane protein folding.
2008 - 2014	Insertion and folding of integral membrane proteins into lipid bilayers - Effects of YaeT and membrane-anchored lipoproteins on membrane-protein folding

Publications

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2001	Tamm, L.K., Arora, A., Kleinschmidt, J.H., 2001. Structure and Assembly of β-Barrel Membrane Proteins. Journal of Biological Chemistry 276, 32399–32402. https://doi.org/10.1074/jbc.R100021200
2001	Kleinschmidt, J.H., Tamm, L.K., 2001. Structure of short-chain phospholipid assemblies investigated by 31P-NMR spectroscopy. BIOPHYSICAL JOURNAL 80, 425A.
2000	Kleinschmidt, J.H., Powell, G.L., Marsh, D., Páli, T.L., 2000. Nonlinear electron paramagnetic resonance studies of the interaction of cytochrome c oxidase with spin-labeled lipids in gel-phase membranes. Biochemistry 39, 2355–2361. https://doi.org/10.1021/bi992478p
2000	Kleinschmidt, J.H., Tamm, L.K., 2000. The folding kinetics of OmpA into large unilamellar vesicles are of second order and depend on the hydrophobic thickness of the lipid bilayer. BIOPHYSICAL JOURNAL 78, 160A.
1999	Kleinschmidt, J.H., den Blaauwen, T., Driessen, A., Tamm, L.K., 1999. Outer membrane protein A of Escherichia coli inserts and folds into lipid bilayers by a concerted mechanism. Biochemistry 38, 5006–5016. https://doi.org/10.1110/ps.8.10.2065
1999	Kleinschmidt, J., Wiener, M.C., Tamm, L.K., 1999. Outer membrane proteine A of E. coli folds into detergent micelles, but not in the presence of monomeric detergent. Protein Science 8, 2065–271.
1999	Kleinschmidt, J., Wiener, M.C., Tamm, L.K., 1999. Refolding of outer membrane protein A in neutral or zwitterlonic detergents requires micelles and does not depend on the detailed chemical structure of the detergent. Biophysical Journal 76, A106.
1999	Kleinschmidt, J.H., Tamm, L., 1999. Time-Resolved Distance Determination by Tryptophan Fluorescence Quenching: Probing Intermediates in Membrane Protein Folding. Biochemistry 38, 4996–5005. https://doi.org/10.1021/bi9824644
1998	Kleinschmidt, J.H., Powell, G.L., Marsh, D., 1998. Cytochrome c-Included Increase of Motionally Restricted Lipid in Reconstituted Cytochrome c Oxidase Membranes, Revealed by Spin-Label ESR Spectroscopy. Biochemistry 37, 11579–11585.
1998	Kleinschmidt, J., den Blaauwen, T., Driessen, A., Tamm, L.K., 1998. Time-resolved fluorescence quenching of single-Trp mutants of outer membrane protein A of E coli. Biophysical Journal 74, A306.

Other Research Activities

from 01/2021	Mitglied der Studiengangsplanungskommission zur Reakkreditierung der Studiengänge Bachelor und Master Biologie Academic self-administration activity
03/2020	Design of a functional tryptophan and cysteine free mutant of BamA for spectroscopic studies on BAM-complex mediated folding and insertion of outer membrane proteins. Poster presentation
SS 2020	Rapid Development with Mentalab‘s Explore: Advanced Signal Processing in Sleep EEG Advising activity
03/2020	The integral membrane protein VDAC can form aqueous folding intermediates with beta-barrel-like structure in the absence of detergent micelles or lipid bilayers. Poster presentation
10/2019	Interactions of the periplasmic chaperone Skp with subunits of the β-barrel assembly machinery complex from Escherichia coli Presentation
02/2018	Interactions of the membrane protein chaperone Skp with BamD of the β-barrel assembly machinery complex from Escherichia coli Poster presentation
WS 2017/2018	Die Adsorption von entfaltetem β-Barrel Assembly Machinery Protein A (BamA) an Lipidmembranen führt in β-Strang neun zur Ausbildung nativer Sekundärstruktur Advising activity
02/2016	Folding and stability of integral membrane proteins in amphipols Presentation
from 08/2014	Kontaktperson der Gesellschaft für Biochemie und Molekularbiologie (GBM) an der Universität Kassel Academic self-administration activity
from 09/2013	Vorsitzender des Prüfungsausschusses des Studiengangs M.Sc. Biologie Academic self-administration activity

Subordinate Organisational Units

Universität Kassel, FB 10, FG Biophysik