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Biophysics

University of Kassel » Fachbereiche » Faculty of Mathematics and Natural Sciences » Institut für Biologie

URL:	http://www.uni-kassel.de/fb10/de/institute/biologie/fachgebiete/biophysik-dach.html

Address:

Heinrich-Plett-Str. 40
34130 Kassel

Persons

Prof. Dr. Jörg Η. Kleinschmidt

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Projects

12/2008 - 09/2021	Insertion and folding of beta-barrel membrane proteins into lipid bilayers - Functions of BamA (YaeT) and of membrane anchored Bam lipoproteins in membrane protein folding.
2008 - 2014	Insertion and folding of integral membrane proteins into lipid bilayers - Effects of YaeT and membrane-anchored lipoproteins on membrane-protein folding

Publications

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1998	Kleinschmidt, J.H., Tamm, L.K., 1998. Time-resolved Trp-fluorescence quenching (TIRFQ): Probing intermediates during membrane protein folding. Biophysical Journal 74, A306.
1997	Kleinschmidt, J.H., Tamm, L.K., 1997. Fluorescence quenching studies on the refolding and membrane insertion of outer membrane protein A (Omp A) of E. coli. Biophysical Journal 72, A315.
1997	Kleinschmidt, J.H., Mahaney, J.E., Thomas, D.D., Marsh, D., 1997. Interaction of Bee Venom Melittin with Zwitterionic and Negatively Charged Phospholipid Bilayers. Biophysical Journal 72, 767–78. https://doi.org/10.1016/S0006-3495(97)78711-3
1997	Kleinschmidt, J.H., Powell, G.L., Marsh, D., 1997. Interactions of Cytochrome c with reconstituted Cytochrome c Oxidase membranes. Evidence for increased Cytochrome c Oxidase boundary lipid induced by Cytochrome c. Biophysical Journal 72, A401.
1997	Kleinschmidt, J.H., Marsh, D., 1997. Spin-label electron spin resonance studies on the interactions of lysine peptides with phospholipid membranes. Biophysical Journal 73, 2546–2555. https://doi.org/https://doi.org/10.1016/S0006-3495(97)78283-3
1996	Kleinschmidt, J.H., Tamm, L.K., 1996. Folding Intermediates of a β-Barrel Membrane Protein. Kinetic Evidence for a Multi-Step Membrane Insertion Mechanism † , ‡. Biochemistry TBD. https://doi.org/10.1021/bi961478b
1996	Kleinschmidt, J.H., Tamm, L.K., 1996. Kinetic studies on the refolding and membrane insertion of outer membrane protein a (OmpA) of E. coli. Biophysical Journal 72, WP384.
1992	Mahaney, J.E., Kleinschmidt, J.H., Marsh, D., Thomas, D.D., 1992. Effects of melittin on lipid-protein interactions in sarcoplasmic reticulum membranes. Biophysical Journal 63, 1513–1522. https://doi.org/10.1021/bi982465w

Other Research Activities

from 01/2021	Mitglied der Studiengangsplanungskommission zur Reakkreditierung der Studiengänge Bachelor und Master Biologie Academic self-administration activity
03/2020	Design of a functional tryptophan and cysteine free mutant of BamA for spectroscopic studies on BAM-complex mediated folding and insertion of outer membrane proteins. Poster presentation
SS 2020	Rapid Development with Mentalab‘s Explore: Advanced Signal Processing in Sleep EEG Advising activity
03/2020	The integral membrane protein VDAC can form aqueous folding intermediates with beta-barrel-like structure in the absence of detergent micelles or lipid bilayers. Poster presentation
10/2019	Interactions of the periplasmic chaperone Skp with subunits of the β-barrel assembly machinery complex from Escherichia coli Presentation
02/2018	Interactions of the membrane protein chaperone Skp with BamD of the β-barrel assembly machinery complex from Escherichia coli Poster presentation
WS 2017/2018	Die Adsorption von entfaltetem β-Barrel Assembly Machinery Protein A (BamA) an Lipidmembranen führt in β-Strang neun zur Ausbildung nativer Sekundärstruktur Advising activity
02/2016	Folding and stability of integral membrane proteins in amphipols Presentation
from 08/2014	Kontaktperson der Gesellschaft für Biochemie und Molekularbiologie (GBM) an der Universität Kassel Academic self-administration activity
from 09/2013	Vorsitzender des Prüfungsausschusses des Studiengangs M.Sc. Biologie Academic self-administration activity

Subordinate Organisational Units

Universität Kassel, FB 10, FG Biophysik