Biochemie - Research Information System | University of Kassel

Biochemie

Universität Kassel » Fachbereiche » FB 10 - Mathematik und Naturwissenschaften » Institut für Biologie

Webseite:

http://www.uni-kassel.de/fb10/de/institute/biologie/fachgebiete/biochemie/startseite.html

Adresse:

Heinrich-Plett-Str. 40
34130 Kassel

Beschreibung

In October 2002 Prof. Friedrich Herberg (Ruhr University of Bochum) joined the faculty of natural sciences at Kassel University. Currently he is leading a group of about fourteen people, focussing cAMP dependent protein kinase (PKA) research. This includes investigating signal transduction pathways using PKA as a model system as well as the development of novel biotechnological and pharmaceutical tools. The PKA-Model system is also used to implement and validate techniques from functional proteomics. Here a main focus is the detailed characterization of molecular interactions within cellular protein networks.

Understanding the structure and function of kinases is essential for understanding complex cellular signal transduction events. The main focus of the group is on research on the molecular basis of fine tuning kinase activity employing biochemical, biophysical, cell biological and bioinformatical technologies, e.g. surface plasmon resonance (SPR), fluorescence polarisation (FP), isothermal titration calorimetry (ITC), Alpha-screen, and bioluminescence resonance energy transfer (BRET). Those BIA–techniques (Biomolecular Interaction Analysis) are applied within a national wide research consortium, the human brain proteome project, funded within the NGFN2 (Nationales Genomforschungsnetzwerk) by the German Federal Ministry of Education and Research (BMBF).

Recently Mass spectrometry (MS) with a newly acquired LC ESI MS instrument (ABI Q-Trap 4000) and molecular modeling technologies have been established and will complete research efforts in proteomics in the near future.

Personen

Ehem. Personen

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Projekte

2 von 5

10/2017 - 09/2020	Conformational Dynamics of LRKK2
09/2016 - 08/2019	Regulationsmechanismen der cGMP-abhängigen Proteinkinase aus Plasmodium falciparum
01/2016 - 12/2018	Application of methyltransferases for the production of high value-added products
07/2013 - 07/2015	Das Nozizeptorschmerz-Modell
04/2010 - 03/2015	Protein-Binder für die Charakterisierung von humanen Proteom-Funktion: Generierung, Validierung und Applikation
04/2010 - 03/2015	Protein Binders for Characterisation of Human Proteome Function: Generation, Validation, Application
10/2009 - 01/2013	Weiterentwickelte Affinitäts-Tools und -Technologien für Hochdurchsatz Studien des menschlichen Proteoms (AffinityProteome)
09/2009 - 05/2012	MedSys-Verbundvorhaben: Modellierung von peripheren Schmerzschaltern
03/2009 - 02/2012	Advanced affinity tools and technologies for high throughput studies of the human proteome - AffinityProteome
02/2009 - 01/2012	MedSys-Verbundvorhaben: "MoPS-Modellierung von peripheren Schmerzschaltern" Teilprojekt E2

Publikationen

1 von 29

2023	Rumpf, M., Pautz, S., Drebes, B., Herberg, F.W., Müller, H.-A., 2023. Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease. International Journal of Molecular Sciences 24, 11913. https://doi.org/10.3390/ijms241511913
2022	Sharma, R., Kim, J.J., Qin, L., Henning, P., Akimoto, M., Van Schouwen, B., Kaur, G., Sankaran, B., MacKenzie, K.R., Melacini, G., Casteel, D.E., Herberg, F.W., Kim, C., 2022. An auto-inhibited state of protein kinase G and implications for selective activation. eLife 11, e79530. https://doi.org/10.7554/eLife.79530
2022	Happ, J.T., Arveseth, C.D., Bruystens, J., Bertinetti, D., Nelson, I.B., Olivieri, C., Zhang, J., Hedeen, D.S., Zhu, J.-F., Capener, J.L., Bröckel, J.W., Vu, L., King, C.C., Ruiz-Perez, V., Ge, X., Veglia, G., Herberg, F.W., Taylor, S.S., Myers, B.R., 2022. A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction. Nature Structural & Molecular Biology 29, 990–999. https://doi.org/10.1038/s41594-022-00838-z
2022	Helton, L.G., Rideout, H.J., Herberg, F.W., Kennedy, E.J., 2022. Leucine rich repeat kinase 2 ( LRRK2 ) peptide modulators: Recent advances and future directions. Peptide Science 114, e24251. https://doi.org/10.1002/pep2.24251
2022	Weng, J.-H., Aoto, P.C., Lorenz, R., Wu, J., Schmidt, S.H., Manschwetus, J.T., Kaila-Sharma, P., Silletti, S., Mathea, S., Chatterjee, D., Knapp, S., Herberg, F.W., Taylor, S.S., 2022. LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. PLoS Biology 20, e3001427. https://doi.org/10.1371/journal.pbio.3001427
2022	Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Yumi Sunaga-Franze, D., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M., Klussmann, E., 2022. Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage. Circulation 146, 1758–1778. https://doi.org/10.1161/circulationaha.122.060210
2022	Singh, R.K., Soliman, A., Guaitoli, G., Störmer, E., Zweydorf, F., Dal Maso, T., Oun, A., van Rillaer, L., Schmidt, S.H., Chatterjee, D., David, J.A., Pardon, E., Schwartz, T.U., Knapp, S., Kennedy, E.J., Steyaert, J., Herberg, F.W., Kortholt, A., Gloeckner, C.J., Versées, W., 2022. Nanobodies as allosteric modulators of Parkinson’s disease-associated LRRK2. Proceedings of the National Academy of Sciences of the United States of America 119, 1–12. https://doi.org/10.1073/pnas.2112712119
2022	Chen, Y., Zizmare, L., Calbiague, V., Yu, S., Herberg, F.W., Schmachtenberg, O., Paquet-Durand, F., Trautwein, C., 2022. Retinal energy metabolism: Photoreceptors switch between Cori, Cahill, and mini-Krebs cycles to uncouple glycolysis from mitochondrial respiration. bioRxiv. https://doi.org/10.1101/2022.06.20.496788
2022	Taylor, S.S., Søberg, K., Kobori, E., Wu, J., Pautz, S., Herberg, F.W., Skålhegg, B.S., 2022. The Tails of Protein Kinase A. Molecular Pharmacology 101, 219–225. https://doi.org/10.1124/molpharm.121.000315
2022	Pellegrino, A., Mükusch, S., Seitz, V., Steinbeck, C., Steinmann, J.-C., Herberg, F.W., Seitz, H., 2022. Transient Receptor Potential Vanilloid 1 Signaling Is Independent on Protein Kinase A Phosphorylation of Ankyrin-Rich Membrane Spanning Protein. Medical Sciences 10, 1–16. https://doi.org/10.3390/medsci10040063

Weitere Forschungsaktivitäten

bis 04/2023	Mitglied des wissenschaftlichen Beirates des Otto-Braun-Fonds Tätigkeit in der akademischen Selbstverwaltung
WS 2019/2020	Interaktionsstudien zwischen der Leucin-Rich- Repeat Kinase 2 und allen humanen 14-3-3 Iso- formen mit Schwerpunkt auf S910, S933 und S935 Betreuungstätigkeit
01/2020	Tagung Biochemistry Retreat 2020 Durchführung eines Kongresses, einer Tagung, einer Vortragsveranstaltung
seit 04/2019	Prodekan des Fachbereichs 10 Mathematik und Naturwissenschaften Tätigkeit in der akademischen Selbstverwaltung
04/2019-03/2025	Prodekan des FB 10 Tätigkeit in der akademischen Selbstverwaltung
01/2019	Tagung Biochemistry Retreat 2019 Durchführung eines Kongresses, einer Tagung, einer Vortragsveranstaltung
01/2018	Tagung Biochemistry Retreat 2018 Durchführung eines Kongresses, einer Tagung, einer Vortragsveranstaltung
07/2017	LRRK2 Workshop in San Diego Durchführung eines Workshops, einer Fort-/Weiterbildungsmaßnahme
01/2017	Tagung Biochemistra Retreat 2017 Durchführung eines Kongresses, einer Tagung, einer Vortragsveranstaltung
SS 2017	Untersuchung der Phosphorylierung der Dynein leichten intermediären Kette (Dlic) durch MAST-Kinase (Dop) während der Zellularizierung des Drosophila melanogaster Betreuungstätigkeit