Roland Klassen - Research Information System | University of Kassel

Dr. Roland Klassen

Research Areas

Mathematics, Natural Sciences

Research Interest

Hefegenetik, non-conventional yeasts, Ribotoxine, tRNA Modifikation, tRNA Reparatur, DNA Reparatur, Mutagenese, DNA Polymerasen, Antimykotika

Academic background

10.1994-03.2000 Studium der Biologie (WWU Münster)

04.2000-10.2004 Promotion im Fachbereich Mikrobiologie (WWU Münster)

Projects as Principal Investigator

12/2015 - 11/2018

Functional cross-talk among modifications in the tRNA anticodon stem-loop

Publications

1 of 5

2023	Schmidt, S., Mayer, K., Klassen, R., Brinkmann, U., Schaffrath, R., 2023. DPH1 Gene Mutations Identify a Candidate SAM Pocket in Radical Enzyme Dph1•Dph2 for Diphthamide Synthesis on EF2. Biomolecules 13, 1655. https://doi.org/10.3390/biom13111655
2023	Ütkür, K., Klassen, R., Schaffrath, R., Schmidt, S., Mayer, K., Brinkmann, U., 2023. DPH1 Gene Mutations Identify a Candidate SAM Pocket in Radical Enzyme Dph1•Dph2 for Diphthamide Synthesis on EF2. Biomolecules 13, TBD. https://doi.org/10.3390/biom13111655
2023	Matos, G.S., Vogt, L., Santos, R.S., Devillars, A., Yoshinaga, M.Y., Miyamoto, S., Schaffrath, R., Montero-Lomeli, M., Klassen, R., 2023. Lipidome remodeling in response to nutrient replenishment requires the tRNA modifier Deg1/Pus3 in yeast. Molecular Microbiology 120, 893–905. https://doi.org/10.1111/mmi.15185
2021	Fuhrmann-Lieker, T., Kubetschek, N., Ziebarth, J., Klassen, R., Seiler, W., 2021. Is the diatom sex clock a clock? Journal of the Royal Society Interface 18, 20210146. https://doi.org/10.1098/rsif.2021.0146
2021	Khonsari, B., Klassen, R., Schaffrath, R., 2021. Role of SSD1 in Phenotypic Variation of Saccharomyces cerevisiae Strains Lacking DEG1-Dependent Pseudouridylation. International Journal of Molecular Sciences 22, 8753. https://doi.org/10.3390/ijms22168753
2020	Klassen, R., Bruch, A., Schaffrath, R., 2020. Induction of protein aggregation and starvation response by tRNA modification defects. Current Genetics. https://doi.org/10.1007/s00294-020-01103-w
2020	Bruch, A., Schaffrath, R., Klassen, R., Laguna, T., Butter, F., 2020. Misactivation of multiple starvation responses in yeast by loss of tRNA modifications. Nucleic Acids Research 48, 7307–7320. https://doi.org/10.1093/nar/gkaa455
2019	Hawer, H., Hammermeister, A., Schaffrath, R., Klassen, R., Ravichandran, K.E., Glatt, S., 2019. Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer. Genes 10, TBD. https://doi.org/10.3390/genes10010019
2018	Klassen, R., Schaffrath, R., Buzzini, P., Ganter, P.F., 2018. Antagonistic Interactions and Killer Yeasts, in: Buzzini, P., Lachance, M.-A., Yurkov, A. (Hrsg.), Yeasts in Natural Ecosystems: Ecology. Springer International Publishing, Cham, S. 229–275. https://doi.org/10.1007/978-3-319-61575-2_9
2018	Schaffrath, R., Klassen, R., 2018. Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression. Scientific Reports 8, 12749. https://doi.org/10.1038/s41598-018-31158-2

Other Research Activities

2009	Post-Doc/Research Scientist I, UTMB (Texas, USA) Stay abroad
0	Additive actions of 5-fluorocytosine and fluconazole in resistant yeast strains Poster presentation
0	Additive actions of 5-fluorocytosine and fluconazole in resistant yeast strains Poster presentation
0	DNA repair pathways contribute to resistance against translational inhibitors in yeast Poster presentation
0	Evidence for additional permeases involved in the toxicity of the antifungal agent 5-fluorocytosine (5-FC) in Saccharomyces cerevisiae Poster presentation
0	Killer toxins of Kluyveromyces lactis and Pichia acaciae: mating inhibition and mating type control Poster presentation
0	Microbial linear plasmids. Microbiology Monographs, Vol. 7 (2007). Springer Verlag, Berlin Heidelberg Publisher activity
0	Novel yeast killer toxins mediate cell cycle arrest during S-phase and activation of the DNA damage checkpoint kinase Rad53 Poster presentation
0	The killer element pPin1-3 of the yeast Pichia inositovora. Poster Poster presentation
0	The Pichia acaciae killer system: Genetic analysis of toxin immunity Poster presentation