Roland Klassen - Research Information System | University of Kassel

Dr. Roland Klassen

Research Areas

Mathematics, Natural Sciences

Research Interest

Hefegenetik, non-conventional yeasts, Ribotoxine, tRNA Modifikation, tRNA Reparatur, DNA Reparatur, Mutagenese, DNA Polymerasen, Antimykotika

Academic background

10.1994-03.2000 Studium der Biologie (WWU Münster)

04.2000-10.2004 Promotion im Fachbereich Mikrobiologie (WWU Münster)

Projects as Principal Investigator

12/2015 - 11/2018

Functional cross-talk among modifications in the tRNA anticodon stem-loop

Publications

4 of 5

2012	Satwika, D., Klassen, R., Meinhardt, F., 2012. Repeated capture of a cytoplasmic linear plasmid by the host nucleus in Debaryomyces hansenii. Yeast 29, 145–154.
2011	Klassen, R., Wemhoff, S., Krause, J., Meinhardt, F., 2011. DNA repair defects sensitize cells to anticodon nuclease yeast killer toxins. Molecular Genetics and Genomics 285, 185–195.
2011	Acharya, N., Klassen, R., Johnson, R., Prakash, L., Prakash, S., 2011. PCNA binding domains in all three subunits of yeast DNA polymerase delta modulate its function in DNA replication. Proceedings of the National Academy of Sciences 108, 17927–17932.
2009	Klassen, R., Meinhardt, F., 2009. Yeast killer toxins: Fundamentals and applications, in: Anke T, W.D. (Eds. . (Hrsg.), The Mycota. Springer Verlag, Berlin Heidelberg, S. 107–130.
2008	Klassen, R., Fricke, J., Pfeiffer, A., Meinhardt, F., 2008. A modified DNA isolation protocol for obtaining pure RT-PCR grade RNA. Biotechnology Letters 30, 1041–1044.
2008	Klassen, R., Paluszynski, J., Meinhardt, F., 2008. Genetic prerequisites for additive or synergistic actions of 5-fluorocytosine and fluconazole in baker’s yeast. Microbiology 154, 3154–3164.
2008	Klassen, R., Paluszynski, J., Wemhoff, S., Pfeiffer, A., Fricke, J., Meinhardt, F., 2008. The primary target of the killer toxin from Pichia acaciae is tRNA(Gln). Molecular Microbiology 69, 681–697.
2007	Jeske, S., Meinhardt, F., Klassen, R., 2007. Extranuclear Inheritance: Virus-like DNA-Elements in Yeast, in: Esser, K. (Hrsg.), Progress in Botany. Springer-Verlag, Berlin Heidelberg, S. 98–129.
2007	Klassen, R., Krampe, S., Meinhardt, F., 2007. Homologous recombination and the yKu70/80 complex exert opposite roles in resistance against the killer toxin from Pichia acaciae. DNA Repair 6, 1864–1875.
2007	Klassen, R., Meinhardt, F., 2007. Linear protein-primed replicating plasmids in eukaryotic microbes. In: Microbial linear plasmids, in: Meinhardt F, K.R. (Eds) (Hrsg.), Microbial linear plasmids. Springer Verlag, Berlin Heidelberg, S. 187–226.

Other Research Activities

2009	Post-Doc/Research Scientist I, UTMB (Texas, USA) Stay abroad
0	Additive actions of 5-fluorocytosine and fluconazole in resistant yeast strains Poster presentation
0	Additive actions of 5-fluorocytosine and fluconazole in resistant yeast strains Poster presentation
0	DNA repair pathways contribute to resistance against translational inhibitors in yeast Poster presentation
0	Evidence for additional permeases involved in the toxicity of the antifungal agent 5-fluorocytosine (5-FC) in Saccharomyces cerevisiae Poster presentation
0	Killer toxins of Kluyveromyces lactis and Pichia acaciae: mating inhibition and mating type control Poster presentation
0	Microbial linear plasmids. Microbiology Monographs, Vol. 7 (2007). Springer Verlag, Berlin Heidelberg Publisher activity
0	Novel yeast killer toxins mediate cell cycle arrest during S-phase and activation of the DNA damage checkpoint kinase Rad53 Poster presentation
0	The killer element pPin1-3 of the yeast Pichia inositovora. Poster Poster presentation
0	The Pichia acaciae killer system: Genetic analysis of toxin immunity Poster presentation