Eugen Franz - Forschungsinformationssystem | Universität Kassel

Dipl. Eugen Franz

Research Areas

Biochemistry (for Biologists)

Work Experience

11/2013 -

Doktorand in der Abteilung Biochemie

Academic background

11/2013 -
Promotion in der Abteilung Biochemie an der Universität Kassel
2012 - 2013
Diplomarbeit in der Abteilung Biochemie an der Universität Kassel
2008 - 2013
Studium der Nanostrukturwissenschaften an der Universität Kassel

Qualifications

2008 - 2013

Diplom Nanostrukturwissenschaftler

Publications

2020	Byun, J., Van, K., Huang, J., Henning, P., Franz, E., Akimoto, M., Herberg, F.W., Kim, C., Melacini, G., 2020. Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase. Journal of Biological Physics and Chemistry 295, 8480–8491. https://doi.org/10.1074/jbc.RA120.013070
2017	Franz, E., Knape, M., Herberg, F.W., 2017. cGMP Binding Domain D Mediates a Unique Activation Mechanism in Plasmodium falciparum PKG. ACS Infectious Diseases 4, 415–423. https://doi.org/10.1021/acsinfecdis.7b00222
2017	Campbell, J.C., Henning, P., Franz, E., Sankaran, B., Herberg, F.W., Kim, C., 2017. Structural Basis of Analog Specificity in PKG I and II. ACS Chemical Biology 12, 2388–2398. https://doi.org/10.1021/acschembio.7b00369
2015	Kim, J.J., Flueck, C., Franz, E., Sanabria-Figueroa, E., Thompson, E., Lorenz, R., Bertinetti, D., Baker, D.A., Herberg, F.W., Kim, C., 2015. Crystal Structures of the carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress. PLoS Pathogens erscheint. https://doi.org/10.1371/journal.ppat.1004639
2015	Wang, Y., Ho, T.G., Franz, E., Hermann, J., Smith, F.D., Hehnly, H., Esseltine, J.L., Hanold, L.E., Murph, M.M., Bertinetti, D., Scott, J.D., Herberg, F.W., Kennedy, E.J., 2015. PKA-Type I Selective Constrained Peptide Disruptors of AKAP Complexes. ACS Chemical Biology 10, 1502–1510. https://doi.org/10.1021/acschembio.5b00009
2015	Franz, E., Kim, J.J., Olga, S., Bertinetti, D., Kim, C., Herberg, F.W., 2015. The role of a parasite-specific D-site in activation of Plasmodium falciparum cGMP-dependent protein kinase, in: Stasch, J.-P., Burnett, J., Schmidt, H., Kuhn, M., Hofmann, F. (Hrsg.), Abstracts from the 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications. BioMed Central Ltd., United Kingdom, S. TBD. https://doi.org/10.1186/2050-6511-16-S1-A51
2014	Wang, Y., Ho, T.G., Bertinetti, D., Neddermann, M., Franz, E., Mo, G.C.H., Schendowich, L.P., Sukhu, A., Spelts, R.C., Zhang, J., Herberg, F.W., Kennedy, E.J., 2014. Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides. ACS Chemical Biology 9, 1386. https://doi.org/10.1021/cb500329z
2014	Wang, Y., Ho, T.G., Bertinetti, D., Neddermann, M., Franz, E., Mo, G.C.H., Schendowich, L.P., Sukhu, A., Spelts, R.C., Zhang, J., Herberg, F.W., Kennedy, E.J., 2014. Isoform-Selective Disruption of AKAP-localized PKA Using Hydrocarbon Stapled Peptides. ACS Chemical Biology 9, 635–42. https://doi.org/10.1021/cb400900r
2013	Lorenz, R., Moon, E., Huang, G., Reger, A., Kim, J., Franz, E., Bertinetti, D., Kim, C., Herberg, F.W., 2013. Transforming PKA into PKG - a structure-function approach to understand cyclic nucleotide selectivity. https://doi.org/10.1186/2050-6511-14-S1-P41

Other Research Activities

2013	Crystal Structures of the Carboxyl cGMP Binding Domain of Plasmodium falciparum cGMP-Dependent Protein Kinase Reveals a Novel Salt Bridge Crucial for Activation Poster presentation