Uni.-Prof. Jörg Η. Kleinschmidt - Research Information System | University of Kassel

Prof. Dr. Jörg Η. Kleinschmidt

Research Areas

Research Interest

Molecular Biophysics, Biochemistry, Life Sciences, Membrane Proteins, Membranes, Proteins, Protein Structure, Lipids, Membrane Structure and -Assembly, Molecular Chaperones, Spectroscopy, especially Electron Spin/Paramagnetic Resonance-, Circular Dichroism-, Fluorescence, and Nuclear Magnetic Resonance-Spectroscopy

Projects as Principal Investigator

12/2008 - 09/2021	Insertion and folding of beta-barrel membrane proteins into lipid bilayers - Functions of BamA (YaeT) and of membrane anchored Bam lipoproteins in membrane protein folding.
2008 - 2014	Insertion and folding of integral membrane proteins into lipid bilayers - Effects of YaeT and membrane-anchored lipoproteins on membrane-protein folding

Projects as Co-Investigator

09/2017 - 03/2021

Wie zelluläre Uhren biologische Funktionen steuern

Publications

1 of 8

2022	Pocanschi, C.L., Kleinschmidt, J.H., 2022. The Thermodynamic Stability of Membrane Proteins in Micelles and Lipid Bilayers Investigated with the Ferrichrom Receptor FhuA. The Journal of Membrane Biology 255, 485–502. https://doi.org/10.1016/S0006-3495(97)78283-3
2019	Kleinschmidt, J.H., 2019. Correction To: Lipid-Protein Interactions. Lipid-Protein Interactions 2003, C1–C4. https://doi.org/10.1007/978-1-4939-9512-7_26
2019	Gerlach, L., Gholami, O., Schürmann, N., Kleinschmidt, J.H., 2019. Folding of β-Barrel Membrane Proteins into Lipid Membranes by Site-Directed Fluorescence Spectroscopy. Methods in Molecular Biology 2003, 465–492. https://doi.org/10.1007/978-1-4939-9512-7_20
2019	Schüßler, A., Herwig, S., Kleinschmidt, J.H., 2019. Kinetics of Insertion and Folding of Outer Membrane Proteins by Gel Electrophoresis. Methods in Molecular Biology 2003, 145–162. https://doi.org/10.1007/978-1-4939-9512-7_7
2019	Kleinschmidt, J.H., 2019. Lipid-Protein Interactions: Methods and Protocols, 682 Pages, 2nd ed. 2019. Springer, New York, NY, New York, NY. https://doi.org/10.1007/978-1-4939-9512-7
2018	Sharma, M., Kleinschmidt, J.H., 2018. Interactions of the Membrane Protein Chaperone Skp with BamD of the β-Barrel Assembly Machinery Complex from E. coli. Biophysical Journal 114, 243a–244a. https://doi.org/10.1016/j.bpj.2017.11.1356
2016	Gerlach, L., Schürmann, N., Kleinschmidt, J.H., 2016. Faltung und Einbau von Außenmembranproteinen in Lipidmembranen. BIOspektrum 22, 700–703.
2016	Gerlach, L., Kleinschmidt, J.H., 2016. The Lipoprotein BamB Facilitates Folding and Insertion of Outer Membrane Protein A (OmpA) into Lipid Membranes Depending on Bilayer Thickness. Biophysical Journal 110, 227a–228a.
2015	Kleinschmidt, J.H., 2015. Review: Folding of β-barrel membrane proteins in lipid bilayers — Unassisted and assisted folding and insertion. Biochimica et Biophysica Acta (BBA)-Biomembranes 1848, 1927–1943. https://doi.org/10.1016/j.bbamem.2015.05.004
2014	Sharma, M., Patel, G.J., Kleinschmidt, J.H., 2014. Folding and Lipid Membrane Interactions of BamD, An Essential Component of the β-Barrel Assembly Machine from Escherichia Coli. Biophysical Journal 106, 264A–264A. https://doi.org/10.1016/j.bpj.2013.11.1553

Lectures

10/2019	Interactions of the periplasmic chaperone Skp with subunits of the β-barrel assembly machinery complex from Escherichia coli Talking with membranes: biogenesis, communications and diseases, Beijing, VR China
02/2016	Folding and stability of integral membrane proteins in amphipols Amphipol Minisymposium 2016, Okinawa

Other Research Activities

2021	Mitglied der Studiengangsplanungskommission zur Reakkreditierung der Studiengänge Bachelor und Master Biologie Academic self-administration activity
2020	Design of a functional tryptophan and cysteine free mutant of BamA for spectroscopic studies on BAM-complex mediated folding and insertion of outer membrane proteins. Poster presentation
2020	Rapid Development with Mentalab‘s Explore: Advanced Signal Processing in Sleep EEG Advising activity
2020	The integral membrane protein VDAC can form aqueous folding intermediates with beta-barrel-like structure in the absence of detergent micelles or lipid bilayers. Poster presentation
2018	Interactions of the membrane protein chaperone Skp with BamD of the β-barrel assembly machinery complex from Escherichia coli Poster presentation
2017	Die Adsorption von entfaltetem β-Barrel Assembly Machinery Protein A (BamA) an Lipidmembranen führt in β-Strang neun zur Ausbildung nativer Sekundärstruktur Advising activity
2014	Kontaktperson der Gesellschaft für Biochemie und Molekularbiologie (GBM) an der Universität Kassel Academic self-administration activity
2013	Vorsitzender des Prüfungsausschusses des Studiengangs M.Sc. Biologie Academic self-administration activity
0	Stellvertretendes Mitglied im Prüfungsausschuss des Studienganges Bachelor Biologie Academic self-administration activity