Uni.-Prof. Jörg Η. Kleinschmidt - Research Information System | University of Kassel

Prof. Dr. Jörg Η. Kleinschmidt

Research Areas

Research Interest

Molecular Biophysics, Biochemistry, Life Sciences, Membrane Proteins, Membranes, Proteins, Protein Structure, Lipids, Membrane Structure and -Assembly, Molecular Chaperones, Spectroscopy, especially Electron Spin/Paramagnetic Resonance-, Circular Dichroism-, Fluorescence, and Nuclear Magnetic Resonance-Spectroscopy

Projects as Principal Investigator

12/2008 - 09/2021	Insertion and folding of beta-barrel membrane proteins into lipid bilayers - Functions of BamA (YaeT) and of membrane anchored Bam lipoproteins in membrane protein folding.
2008 - 2014	Insertion and folding of integral membrane proteins into lipid bilayers - Effects of YaeT and membrane-anchored lipoproteins on membrane-protein folding

Projects as Co-Investigator

09/2017 - 03/2021

Wie zelluläre Uhren biologische Funktionen steuern

Publications

8 of 8

1997	Kleinschmidt, J.H., Marsh, D., 1997. Spin-label electron spin resonance studies on the interactions of lysine peptides with phospholipid membranes. Biophysical Journal 73, 2546–2555. https://doi.org/https://doi.org/10.1016/S0006-3495(97)78283-3
1996	Kleinschmidt, J.H., Tamm, L.K., 1996. Folding Intermediates of a β-Barrel Membrane Protein. Kinetic Evidence for a Multi-Step Membrane Insertion Mechanism † , ‡. Biochemistry TBD. https://doi.org/10.1021/bi961478b
1996	Kleinschmidt, J.H., Tamm, L.K., 1996. Kinetic studies on the refolding and membrane insertion of outer membrane protein a (OmpA) of E. coli. Biophysical Journal 72, WP384.
1992	Mahaney, J.E., Kleinschmidt, J.H., Marsh, D., Thomas, D.D., 1992. Effects of melittin on lipid-protein interactions in sarcoplasmic reticulum membranes. Biophysical Journal 63, 1513–1522. https://doi.org/10.1021/bi982465w

Lectures

10/2019	Interactions of the periplasmic chaperone Skp with subunits of the β-barrel assembly machinery complex from Escherichia coli Talking with membranes: biogenesis, communications and diseases, Beijing, VR China
02/2016	Folding and stability of integral membrane proteins in amphipols Amphipol Minisymposium 2016, Okinawa

Other Research Activities

2021	Mitglied der Studiengangsplanungskommission zur Reakkreditierung der Studiengänge Bachelor und Master Biologie Academic self-administration activity
2020	Design of a functional tryptophan and cysteine free mutant of BamA for spectroscopic studies on BAM-complex mediated folding and insertion of outer membrane proteins. Poster presentation
2020	Rapid Development with Mentalab‘s Explore: Advanced Signal Processing in Sleep EEG Advising activity
2020	The integral membrane protein VDAC can form aqueous folding intermediates with beta-barrel-like structure in the absence of detergent micelles or lipid bilayers. Poster presentation
2018	Interactions of the membrane protein chaperone Skp with BamD of the β-barrel assembly machinery complex from Escherichia coli Poster presentation
2017	Die Adsorption von entfaltetem β-Barrel Assembly Machinery Protein A (BamA) an Lipidmembranen führt in β-Strang neun zur Ausbildung nativer Sekundärstruktur Advising activity
2014	Kontaktperson der Gesellschaft für Biochemie und Molekularbiologie (GBM) an der Universität Kassel Academic self-administration activity
2013	Vorsitzender des Prüfungsausschusses des Studiengangs M.Sc. Biologie Academic self-administration activity
0	Stellvertretendes Mitglied im Prüfungsausschuss des Studienganges Bachelor Biologie Academic self-administration activity