Univ.-Prof. Friedrich Wilhelm Herberg - Research Information System | University of Kassel

Prof. Dr. Friedrich Wilhelm Herberg

Academic background

2018
Sabbatical at the University of Georgia, Athens (Department of Biochemistry & Molecular Biology)

Since 2016
Vice Chair, Centre for Interdisciplinary Nanostructure Science and Technology (CINSaT), Section Biosensing
University of Kassel, Germany

2013 - 2014
Sabbatical at the Prof. Susan S. Taylor lab at the University of California, San Diego (Susan S. Taylor Laboratory)

Since 2014
Ombudsmann
University of Kassel, Germany

2013 - 2018
Executive director of the Institute of Biology (Board of directors)
University of Kassel, Germany

Since 2013
Member of the Forschungskommission
University of Kassel, Germany

Since 2012
Chairman and founding member of the new Promotionskolleg "Functional analysis of modifications on macromolecules"
University of Kassel, Germany

2010 - 2013
Dean of the Faculty of Mathematics and Natural Science (FB10)
University of Kassel, Germany

2008 - 2011
Vice director of the Institute of Biology (Board of directors)
University of Kassel, Germany

2008 - 2013
Dean of the Faculty of Natural Science (FB10)
University of Kassel, Germany

Since 2008
Mentor for women in science (SciMento)
University Frankfurt, Germany

2007 - 2010
Deputy speaker of the Centre for Interdisciplinary Nanostructure Science and Technology (CINSaT)
University of Kassel, Germany

2006-2011
Chairman and founding member of the Promotionskolleg "Proteomics"
University of Kassel, Germany

2005-2008
Executive director of the Institute of Biology (Board of directors)
University of Kassel, Germany

Since 2003
CSO of BIAFFIN GmbH & CoKG
Kassel, Germany

2002-2013
Member and chair of the Finnish Academy of Science

Since 2002
Founding member of the Centre for Interdisciplinary Nanostructure Science and Technology (CINSaT)
University of Kassel, Germany

Since October 2002
Full professor for Biochemistry, (C4)
University of Kassel, Germany

2002
Assistant professor
Physiological Chemistry, Ruhr-University Bochum, Germany

2001
Foundation of BIAFFIN GmbH & CoKG
Biomolecular Interactionanalysis
Bochum, Germany

2000
Foundation of Zimmermann und Herberg GbR
Bochum, Germany

1999
Habilitation, Venia legendi "Struktur, Funktion und Regulation zyklo-Nukleotid-abhängiger Proteinkinasen"
in Physiological Chemistry
Physiological Chemistry, Ruhr-University Bochum, Germany

1998
"Bennigsen-Foerder Preis" of Nordrhein-Westfalen (federal state)
Germany

1997 - 2001
Research Associate (group leader)
Physiological Chemistry, Ruhr-University Bochum, Germany

1994 - 1997
Research Assistant (group leader)
Physiological Chemistry, Ruhr-University Bochum, Germany

1993 - 1994
Assistant Project Scientist
Department of Chemistry, University of California, San Diego, USA

1990 - 1993
Postdoc
Department of Chemistry, University of California, San Diego, USA

1987 - 1990
PhD in Physiological Chemistry "Isolation und biochemische Charakterisierung von Myotommembranen des Lanzettfischchens Branchiostoma lanceolatum"
Medical Faculty Ruhr-University Bochum, Germany

1980 - 1987
Studied Biology and Chemistry
Ruhr-University Bochum, Germany

Projects as Principal Investigator

1 of 4

04/2022 - 09/2026	GRK 2749/1_Multiscale Clocks_TP 8
12/2021 - 06/2023	Exploring Allosteric regulation of LRRK2
01/2021 - 12/2023	Affinitätsbasierte Antikörper-Spezifikat
08/2020 - 07/2021	Structural Window into LRRK2
06/2020 - 05/2023	TargetRD
03/2020 - 07/2021	CoLab - Bioökonomie
10/2019 - 12/2020	Allosteric Targeting of LRRK2
07/2019 - 07/2021	LRRK2 - Specific Nanobodies
06/2018 - 03/2022	RHODOLIVE
05/2018 - 10/2020	structure and function of LRRK2 (MJFF)

Projects as Co-Investigator

09/2017 - 03/2021	Wie zelluläre Uhren biologische Funktionen steuern
2017 - 2021	PhosMOrg - Phosphoregulation of Biomolecules: from Mechanisms to Organisms
03/2014 - 08/2014	Lab-on-a-chip biosensor for multiple biomarker detection from human serum with increased analyte binding and reduced background (Vorbereitung Vollantrag)
11/2006 - 2008	Identifizierung therapeutischer Substanzen, die zielgerichtet kompartimentierte cAMP Signalnetzwerke in humanen Krankheiten ansprechen
10/2004 - 09/2007	Human Brain Proteome Project (HBPP2): TP3-Funktionelle Analyse von Proteinkomplexen
11/2002 - 10/2005	Verankerte cAMP-Signale - Implikation in die Behandlung menschlicher Erkrankungen

Publications

1 of 22

2023	Rumpf, M., Pautz, S., Drebes, B., Herberg, F.W., Müller, H.-A., 2023. Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease. International Journal of Molecular Sciences 24, 11913. https://doi.org/10.3390/ijms241511913
2022	Sharma, R., Kim, J.J., Qin, L., Henning, P., Akimoto, M., Van Schouwen, B., Kaur, G., Sankaran, B., MacKenzie, K.R., Melacini, G., Casteel, D.E., Herberg, F.W., Kim, C., 2022. An auto-inhibited state of protein kinase G and implications for selective activation. eLife 11, e79530. https://doi.org/10.7554/eLife.79530
2022	Happ, J.T., Arveseth, C.D., Bruystens, J., Bertinetti, D., Nelson, I.B., Olivieri, C., Zhang, J., Hedeen, D.S., Zhu, J.-F., Capener, J.L., Bröckel, J.W., Vu, L., King, C.C., Ruiz-Perez, V., Ge, X., Veglia, G., Herberg, F.W., Taylor, S.S., Myers, B.R., 2022. A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction. Nature Structural & Molecular Biology 29, 990–999. https://doi.org/10.1038/s41594-022-00838-z
2022	Helton, L.G., Rideout, H.J., Herberg, F.W., Kennedy, E.J., 2022. Leucine rich repeat kinase 2 ( LRRK2 ) peptide modulators: Recent advances and future directions. Peptide Science 114, e24251. https://doi.org/10.1002/pep2.24251
2022	Weng, J.-H., Aoto, P.C., Lorenz, R., Wu, J., Schmidt, S.H., Manschwetus, J.T., Kaila-Sharma, P., Silletti, S., Mathea, S., Chatterjee, D., Knapp, S., Herberg, F.W., Taylor, S.S., 2022. LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. PLoS Biology 20, e3001427. https://doi.org/10.1371/journal.pbio.3001427
2022	Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Yumi Sunaga-Franze, D., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M., Klussmann, E., 2022. Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage. Circulation 146, 1758–1778. https://doi.org/10.1161/circulationaha.122.060210
2022	Singh, R.K., Soliman, A., Guaitoli, G., Störmer, E., Zweydorf, F., Dal Maso, T., Oun, A., van Rillaer, L., Schmidt, S.H., Chatterjee, D., David, J.A., Pardon, E., Schwartz, T.U., Knapp, S., Kennedy, E.J., Steyaert, J., Herberg, F.W., Kortholt, A., Gloeckner, C.J., Versées, W., 2022. Nanobodies as allosteric modulators of Parkinson’s disease-associated LRRK2. Proceedings of the National Academy of Sciences of the United States of America 119, 1–12. https://doi.org/10.1073/pnas.2112712119
2022	Chen, Y., Zizmare, L., Calbiague, V., Yu, S., Herberg, F.W., Schmachtenberg, O., Paquet-Durand, F., Trautwein, C., 2022. Retinal energy metabolism: Photoreceptors switch between Cori, Cahill, and mini-Krebs cycles to uncouple glycolysis from mitochondrial respiration. bioRxiv. https://doi.org/10.1101/2022.06.20.496788
2022	Taylor, S.S., Søberg, K., Kobori, E., Wu, J., Pautz, S., Herberg, F.W., Skålhegg, B.S., 2022. The Tails of Protein Kinase A. Molecular Pharmacology 101, 219–225. https://doi.org/10.1124/molpharm.121.000315
2022	Pellegrino, A., Mükusch, S., Seitz, V., Steinbeck, C., Steinmann, J.-C., Herberg, F.W., Seitz, H., 2022. Transient Receptor Potential Vanilloid 1 Signaling Is Independent on Protein Kinase A Phosphorylation of Ankyrin-Rich Membrane Spanning Protein. Medical Sciences 10, 1–16. https://doi.org/10.3390/medsci10040063

Other Research Activities

1 of 4

2023	Mitglied des wissenschaftlichen Beirates des Otto-Braun-Fonds Academic self-administration activity
2020	Interaction-studies between the leucine-rich-repeat kinase 2 and all human 14-3-3 isoforms focussing on S910, S933 and S935 Advising activity
2020	Tagung Biochemistry Retreat 2020 Conference or similar event
2019	Prodekan des Fachbereichs 10 Mathematik und Naturwissenschaften Academic self-administration activity
2019	Prodekan des FB 10 Academic self-administration activity
2019	Tagung Biochemistry Retreat 2019 Conference or similar event
2018	Tagung Biochemistry Retreat 2018 Conference or similar event
2017	LRRK2 Workshop in San Diego Workshop or training
2017	Tagung Biochemistra Retreat 2017 Conference or similar event
2017	Investigation of the phosphorylation of the Dynein light intermediate chain (Dlic) by MAST kinase (Dop) during the cellularization of Drosophila melanogaster Advising activity