Journal article
Combined Funnel, Concentrator, and Particle Valve Functional Element for Magnetophoretic Bead Transport Based on Engineered Magnetic Domain Patterns
Publication Details
Authors: | Huhnstock, R.; Paetzold, L.; Merkel, M.; Kuświk, P.; Ehresmann, A. |
Publication year: | 2023 |
Pages range : | TBD |
DOI-Link der Erstveröffentlichung: |
Controlled actuation of superparamagnetic beads (SPBs) within a microfluidic environment using tailored dynamic magnetic field landscapes (MFLs) is a potent approach for the realization of point-of-care diagnostics within Lab-on-a-chip (LOC) systems. Making use of an engineered magnetic domain pattern as the MFL source, a functional LOC-element with combined magnetophoretic {\textquotedbl}funnel{\textquotedbl}, concentrator, and {\textquotedbl}valve{\textquotedbl} functions for micron-sized SPBs is presented. A parallel-stripe domain pattern design with periodically decreasing/increasing stripe lengths is fabricated in a topographically flat continuous exchange biased (EB) thin film system by ion bombardment induced magnetic patterning (IBMP). It is demonstrated that, upon application of external magnetic field pulses, a fully reversible concentration of SPBs at the domain pattern's focal point occurs. In addition, it is shown that this functionality may be used as an SPB {\textquotedbl}funnel{\textquotedbl}, allowing only a maximum number of particles to pass through the focal point. Adjusting the pulse time length, the focal point can be clogged up for incoming SPBs, resembling an on/off switchable particle {\textquotedbl}valve{\textquotedbl}. The observations are supported by quantitative theoretical force considerations.