Rezension

Diphthamide - a conserved modification of eEF2 with clinical relevance.



Details zur Publikation
Autor(inn)en:
Schaffrath, R.

Publikationsjahr:
2024
Zeitschrift:
Trends in Molecular Medicine
Seitenbereich:
164-177
Jahrgang/Band :
30
Heftnummer:
2
Erste Seite:
164
Letzte Seite:
177
ISSN:
1471-4914
DOI-Link der Erstveröffentlichung:


Zusammenfassung, Abstract
Diphthamide, a complex modification on eukaryotic translation elongation factor 2 (eEF2), assures reading-frame fidelity during translation. Diphthamide and enzymes for its synthesis are conserved in eukaryotes and archaea. Originally identified as target for diphtheria toxin (DT) in humans, its clinical relevance now proves to be broader than the link to pathogenic bacteria. Diphthamide synthesis enzymes (DPH1 and DPH3) are associated with cancer, and DPH gene mutations can cause diphthamide deficiency syndrome (DDS). Finally, new analyses provide evidence that diphthamide may restrict propagation of viruses including SARS-CoV-2 and HIV-1, and that DPH enzymes are targeted by viruses for degradation to overcome this restriction. This review describes how diphthamide is synthesized and functions in translation, and covers its clinical relevance in human development, cancer, and infectious diseases.

Zuletzt aktualisiert 2024-26-03 um 15:17