Aufsatz in einer Fachzeitschrift
Electric Field-Driven Disruption of a Native beta-Sheet Protein Conformation and Generation of a Helix-Structure
Details zur Publikation
Autor(inn)en: | Ojeda May, P.; Garcia, M. |
Publikationsjahr: | 2010 |
Zeitschrift: | Biophysical Journal |
Seitenbereich: | 595-599 |
Abkürzung der Fachzeitschrift: | Biophys. J. |
Jahrgang/Band : | 99 |
Erste Seite: | 595 |
Letzte Seite: | 599 |
ISSN: | 0006-3495 |
eISSN: | 1542-0086 |
Zusammenfassung, Abstract
We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein.
We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein.
