Journal article
Hypoxia activates IKK-NF-kappa B and the immune response in Drosophila melanogaster
Publication Details
Authors: | Bandarra, D.; Biddlestone, J.; Mudie, S.; Müller, H.; Rocha, S. |
Publisher: | PORTLAND PRESS LTD |
Publication year: | 2014 |
Journal: | Bioscience Reports |
Pages range : | e00127429-440 |
Volume number: | 34 |
Start page: | 429 |
End page: | 440 |
Number of pages: | 12 |
ISSN: | 0144-8463 |
eISSN: | 1573-4935 |
DOI-Link der Erstveröffentlichung: |
Abstract
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival. In mammalian cells, hypoxia not only activates the HIF (hypoxia-inducible factor) family, but also additional transcription factors such as NF-kappa B (nuclear factor kappa B). Here we show that hypoxia activates the IKK-NF-kappa B [I kappa B (inhibitor of nuclear factor kappa B)-NF-kappa B] pathway and the immune response in Drosophila melanogaster. We show that NF-kappa B activation is required for organism survival in hypoxia. Finally, we identify a role for the tumour suppressor Cyld, as a negative regulator of NF-kappa B in response to hypoxia in Drosophila. The results indicate that hypoxia activation of the IKK-NF-kappa B pathway and the immune response is an important and evolutionary conserved response.
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival. In mammalian cells, hypoxia not only activates the HIF (hypoxia-inducible factor) family, but also additional transcription factors such as NF-kappa B (nuclear factor kappa B). Here we show that hypoxia activates the IKK-NF-kappa B [I kappa B (inhibitor of nuclear factor kappa B)-NF-kappa B] pathway and the immune response in Drosophila melanogaster. We show that NF-kappa B activation is required for organism survival in hypoxia. Finally, we identify a role for the tumour suppressor Cyld, as a negative regulator of NF-kappa B in response to hypoxia in Drosophila. The results indicate that hypoxia activation of the IKK-NF-kappa B pathway and the immune response is an important and evolutionary conserved response.
Keywords
Cyld, Drosophila, hypoxia, IKK, immune response, NF-kappa B
